// Research & publications

Science you
can cite.

Every performance claim in IntelliForm traces back to validated research. Our methodology is peer-reviewed, openly available, and actively expanding — from Bayesian formulation optimization to QSAR biodegradability prediction.

Featured
publication.

All
publications.

2026
ChemRxiv Preprint

What Eighteen Properties Taught Us: Multi-Objective Bayesian Formulation Intelligence for Green Chemistry

Shehan S. Makani
ChemRxiv · DOI: 10.26434/chemrxiv.15000857/v1

Two-stage surrogate-assisted NSGA-III pipeline, EcoMetrics sustainability scoring (ρ = 0.83 vs. 47 ISO 14040 datasets), QSAR biodegradability R² = 0.89, Circular Formulation Engine. ~8,000× optimization speedup.

2025
NJIT STEM Showcase · SSRN

Smart Manufacturing in Chemicals: The Role of AI and Integrated Equipment in Sustainable Process Innovation

Shehan S. Makani
NJIT STEM for Success Showcase #104 · SSRN ID: 5773223 · UIC Indigo Repository

Examines how AI, smart sensors, and digital twins are transforming chemical manufacturing. Presents case studies in process optimization, predictive maintenance, and sustainable production scale-up using integrated AI-equipment systems.

2025
NJIT STEM Showcase

From Chemistry to Conscious Code: How AI is Shaping the Next Generation of Sustainable Innovation

Shehan S. Makani
NJIT STEM for Success Showcase #103

Explores the convergence of AI and chemistry for sustainable industrial innovation — from natural language interfaces to autonomous formulation systems. Presents a framework for responsible AI deployment in specialty chemical production.

2025
ResearchGate

Democratizing Chemical Procurement: An AI-Driven Marketplace for Low MOQ Sourcing in Specialty Chemicals

Shehan S. Makani
ResearchGate Preprint

Presents a framework for AI-mediated specialty chemical procurement, enabling SMEs to access low minimum order quantities through intelligent supplier matching, automated COA/SDS verification, and REACH compliance screening.

Active

IntelliForm: An Agentic Multi-Objective Bayesian Formulation Intelligence Platform

Shehan S. Makani · ChemeNova LLC
Journal of Chemical Information and Modeling · Submission ref: ci-2026-00721h

Full-length article detailing the IntelliForm platform architecture, NSGA-III surrogate pipeline, EcoMetrics validation, and benchmarking against existing formulation approaches across 7 industry verticals.

Active

What Eighteen Properties Taught Us: NSGA-III Formulation Intelligence Across Specialty Chemical Verticals

Shehan S. Makani · ChemeNova LLC
npj Computational Materials · Nature Portfolio · IF ~12

Extended article with complete 5-figure publication-quality visualization suite, supplementary information, and cover letter submitted to npj Computational Materials for peer review.

Active

Article Submission: Autonomous Green Formulation via Multi-Agent AI and Surrogate-Assisted Optimization

Shehan S. Makani · ChemeNova LLC
Nature Chemical Engineering · IF ~12 · Nature Portfolio

Complete Article submission including full manuscript, cover letter with reviewer suggestions, and Supplementary Information. Covers the full IntelliForm ecosystem from Bayesian optimization to Molecular Memory Network.

2025
Medium

From Lab to Market: The Journey of Green Chemistry Innovations

Shehan Makani
Medium · @shehanmakani · September 2025

Accessible overview of the path from laboratory formulation research to commercial green chemistry products — covering scale-up challenges, regulatory hurdles, and the role of AI in accelerating go-to-market timelines.

Active research
topics.

⚗️

Multi-Objective Formulation Optimization

NSGA-III surrogate-assisted optimization for simultaneous cost, performance, and sustainability objectives. Bayesian Gaussian process models as surrogates for computationally expensive property evaluations.

  • Surrogate model fidelity and speedup tradeoffs
  • Adaptive retraining from pilot batch data
  • Pareto front visualization and decision support
🔬

QSAR Predictive Modeling

Machine learning models for quantitative structure-activity relationships in specialty chemicals. 1,613 Mordred molecular descriptors combined with ensemble regression for property prediction from SMILES strings.

  • Biodegradability prediction (R² = 0.89 validated)
  • Ecotoxicity and bioaccumulation from structure
  • Solubility and partition coefficient models
🌱

Life Cycle Assessment Integration

Automated carbon footprint calculation and sustainability scoring aligned with ISO 14040/14044. EcoMetrics validation against industry LCA datasets and integration of Scope 1/2/3 emissions into formulation optimization.

  • ISO 14067 product carbon footprint automation
  • EU CBAM compliance data generation
  • Circular economy metrics for chemical products
🧠

Molecular Memory Networks

Knowledge graph architectures for retaining institutional formulation knowledge across R&D cycles. Negative knowledge capture — encoding what NOT to formulate — from real experimental failure data.

  • Formulation decision graph construction
  • Failure mode embedding and retrieval
  • Adaptive learning from pilot batch outcomes
🤖

Agentic Chemistry Systems

Multi-model AI architectures for autonomous chemical formulation. Natural language parsing, regulatory compliance verification, and consensus intelligence across specialized chemistry AI models.

  • 5-model council architecture design
  • Confidence scoring and uncertainty quantification
  • Tool-augmented LLM for chemistry tasks
🚀

Extreme Environment Materials

Computational approaches to formulating materials for space, aerospace, and hypersonic applications. Outgassing prediction, radiation dose tolerance modeling, and cryogenic property estimation from molecular structure.

  • ASTM E595 outgassing prediction from SMILES
  • Radiation-induced degradation modeling
  • Thermal stability in vacuum environments

Academic
collaborations.

N

New Jersey Institute of Technology

Newark, NJ · Tech MBA Program
STEM for Success Showcase · Advisor: Prof. Ravi Navindra
Smart Manufacturing research collaboration

U

University of Illinois Chicago

Chicago, IL · NSF-START Program
CIMSEPP IUCRC · Advisor: Prof. Meneesh Singh
Pharmaceutical manufacturing · UIC Indigo repository

Interested in a research collaboration? We actively seek partnerships with academic institutions, national laboratories, and industry research groups working at the intersection of AI and chemistry. Contact us →

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